Ethyl bromoacetate → Ethyl 2-((2-methoxyquinolin-8-yl)oxy)acetate
反応式
[CH3:1][O:2][C:3]1[CH:12]=[CH:11][C:10]2[C:5](=[C:6]([OH:13])[CH:7]=[CH:8][CH:9]=2)[N:4]=1.Br[CH2:15][C:16]([O:18][CH2:19][CH3:20])=[O:17].C([O-])([O-])=O.[K+].[K+]>CC#N>[CH3:1][O:2][C:3]1[CH:12]=[CH:11][C:10]2[C:5](=[C:6]([O:13][CH2:15][C:16]([O:18][CH2:19][CH3:20])=[O:17])[CH:7]=[CH:8][CH:9]=2)[N:4]=1参加物
5
反応条件
- 温度
- 80 °C
実験手順
To a solution of 2-methoxyquinolin-8-ol (500 mg, 2.86 mmol) in MeCN (10 mL) was added ethyl 2-bromoacetate (501 mg, 3.0 mmol) and K2CO3 (789 mg, 5.72 mmol). The mixture was stirred at 80° C. for 5 h. The mixture was filtered and the filtrate evaporated to give the desired compound (700 mg, yield 94%). LCMS (m/z): 262.1 [M+H]+
後処理
- filtrationThe mixture was filtered
- customthe filtrate evaporated
出典と根拠
- ORDレコード
- ord-c902d5599be9457f916eefec9bba6236
- 出典データセット
- uspto-grants-2016_02
- 特許番号
- US09266836B2
反応ノート
読み込み中…