Propyl isocyanate → 1-Propylcarbamoylcyclopropanesulfonamide tert-butylcarbamate

HRID 17804

反応式

HRID 17804 の反応式
[C:1]([NH:5][C:6](=[O:8])[OH:7])([CH3:4])([CH3:3])[CH3:2].C[O:10][CH2:11][C:12]1([S:15]([NH2:18])(=[O:17])=[O:16])[CH2:14][CH2:13]1.[CH2:19]([N:22]=C=O)[CH2:20][CH3:21]>>[C:1]([NH:5][C:6](=[O:7])[OH:8])([CH3:4])([CH3:3])[CH3:2].[CH2:19]([NH:22][C:11]([C:12]1([S:15]([NH2:18])(=[O:17])=[O:16])[CH2:14][CH2:13]1)=[O:10])[CH2:20][CH3:21]

参加物

3

反応物 2

HCID 61033Propyl isocyanateHCID 667523821-Methoxymethylcyclopropylsulfonylamine tert-butylcarbamate

生成物 1

HCID 667532941-Propylcarbamoylcyclopropanesulfonamide tert-butylcarbamate収率 100%

実験手順

This compound was obtained in a crude 100% yield according to the procedure described for the synthesis of 1-methoxymethylcyclopropylsulfonylamine tert-butyl-carbamate except that 1.10 equivalents of n-propyl isocyanate was used as the electrophile. The compound was taken directly into the next reaction without purification: 1H NMR (CDCl3) δ 0.10 (m, 2H), 0.51 (m, 2H), 0.67 (m, 1H), 1.10 (m, 2H), 1.49 (s, 9H), 1.62 (m, 2H), 1.87 (d, J=7.0 Hz, 2H).

後処理

  1. customThis compound was obtained in a crude 100% yield
  2. customThe compound was taken directly into the next reaction without purification

出典と根拠

ORDレコード
ord-d02dce065cef470d8f389fc3a6d68a94
出典データセット
uspto-grants-2010_06
特許番号
US07741281B2

関連ノート

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