2-Bromododecanoic acid → 2-chlorododecanoic Acid

HRID 1780686

反応式

HRID 1780686 の反応式
Br[CH:2]([CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH3:15])[C:3]([OH:5])=[O:4].[Cl-:16].[Ca+2].[Cl-]>C(#N)C.[Cl-].C([N+](CC)(CC)CC)C>[Cl:16][CH:2]([CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH3:15])[C:3]([OH:5])=[O:4]

参加物

5

反応物 2

HCID 669802-Bromododecanoic acidHCID 5284359Calcium Chloride

生成物 1

HCID 43873702-chlorododecanoic Acid

試薬・触媒・溶媒 2

HCID 5946Tetraethylammonium Chloride触媒HCID 6342Acetonitrile溶媒

実験手順

To 2-bromododecanoic acid (1 g), after having been dissolved in acetonitrile (50 ml), were added calcium chloride (2 g) and tetraethylammonium chloride (1 g), and the mixture was heated under reflux for 4 hours. The reaction mixture was filtered, concentrated and distributed into ethyl acetate and water, and the ethyl acetate layer was dried over anhydrous sodium sulfate and concentrated to give 2-chlorododecanoic acid.

後処理

  1. temperaturethe mixture was heated
  2. temperatureunder reflux for 4 hours
  3. filtrationThe reaction mixture was filtered
  4. concentrationconcentrated
  5. dry with materialthe ethyl acetate layer was dried over anhydrous sodium sulfate
  6. concentrationconcentrated

出典と根拠

ORDレコード
ord-4d66a7dbe24942be852784d3284035db
出典データセット
uspto-grants-1997_05
特許番号
US05631238

関連ノート

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