2',3'-Dimethyl-3-nitrobenzanilide → 3-amino-N-(2,3-dimethylphenyl)benzamide

HRID 1780804

反応式

HRID 1780804 の反応式
[N+:1]([C:4]1[CH:5]=[C:6]([CH:18]=[CH:19][CH:20]=1)[C:7]([NH:9][C:10]1[CH:15]=[CH:14][CH:13]=[C:12]([CH3:16])[C:11]=1[CH3:17])=[O:8])([O-])=O.[H][H]>CO.O1CCCC1.[Pd]>[NH2:1][C:4]1[CH:5]=[C:6]([CH:18]=[CH:19][CH:20]=1)[C:7]([NH:9][C:10]1[CH:15]=[CH:14][CH:13]=[C:12]([CH3:16])[C:11]=1[CH3:17])=[O:8]

参加物

6

反応物 2

HCID 8165712',3'-Dimethyl-3-nitrobenzanilideHCID 178418361HCID 178418361、化合物

生成物 1

HCID 64565863-amino-N-(2,3-dimethylphenyl)benzamide

試薬・触媒・溶媒 3

HCID 23938Palladium触媒HCID 887Methanol溶媒HCID 8028Tetrahydrofuran溶媒

実験手順

To a solution of 1 (1 g) in 70 mL methanol and 30 mL of tetrahydrofuran was added 10% Pd/C (0.2 g) under nitrogen atmosphere. Hydrogen was applied to the mixture at 60 psi for 16 h. The mixture was filtered and concentrated in vacuo to obtain the product. NMR (300 MHz, CDCl3) δ 7.71 (1H, s), 7.55 (1H, d, J=9 Hz), 7.23 (1H, t, J=9 Hz), 7.19 (1H, s), 7.14 (1H, t, J=9 Hz), 7.04 (1H, d, J=9 Hz), 6.82 (1H, d, J=9 Hz), 3.84 (2H, b), 2.32 (3H, s), 2.20 (2H, s).

後処理

  1. filtrationThe mixture was filtered
  2. concentrationconcentrated in vacuo
  3. customto obtain the product

出典と根拠

ORDレコード
ord-cbf59ca0dd2742b38f7a171f2f89ecae
出典データセット
uspto-grants-1997_05
特許番号
US05631280

関連ノート

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