Sodium Hydroxide → HCID 54134609、化合物

HRID 1780839ノート

反応式

HRID 1780839 の反応式
[CH:1]1([CH2:4][O:5][C:6]2[CH:7]=[C:8]([CH:11]=[CH:12][C:13]=2[O:14][CH:15]([F:17])[F:16])C=O)[CH2:3][CH2:2]1.[BH4-].[Na+].[OH-:20].[Na+]>C(O)C>[CH:1]1([CH2:4][O:5][C:6]2[CH:7]=[C:8]([OH:20])[CH:11]=[CH:12][C:13]=2[O:14][CH:15]([F:17])[F:16])[CH2:3][CH2:2]1

参加物

5

反応物 3

HCID 14798Sodium HydroxideHCID 4311764Sodium borohydrideHCID 189736983-(Cyclopropylmethoxy)-4-(difluoromethoxy)benzaldehyde

生成物 1

HCID 54134609HCID 54134609、化合物

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

Crude 3-cyclopropylmethoxy-4-difluoromethoxybenzaldehyde (26.4 g) in absolute ethanol (200 mL) was treated with sodium borohydride (8.23 g, 217 mmol) under an argon atmosphere at room temperature for 0.33 h. Ten percent aqueous sodium hydroxide (150 mL) was added, the ethanol was removed in vacuo and the aqueous residue was extracted three times with ether. The organic extract was washed twice with brine, was dried (sodium sulfate), was filtered and was evaporated to a pale yellow oil (24.4 g).

後処理

  1. customthe ethanol was removed in vacuo
  2. extractionthe aqueous residue was extracted three times with ether
  3. extractionThe organic extract
  4. washwas washed twice with brine
  5. dry with materialwas dried (sodium sulfate)
  6. filtrationwas filtered
  7. customwas evaporated to a pale yellow oil (24.4 g)

出典と根拠

ORDレコード
ord-4456a194c8a0409daf7209caa3d8ab35
出典データセット
uspto-grants-1997_05
特許番号
US05631286

反応ノート

読み込み中…