Sodium Carbonate → 2-amino-N'-hydroxypyridine-4-carboximidamide
反応式
[NH2:1][C:2]1[CH:7]=[C:6]([C:8]#[N:9])[CH:5]=[CH:4][N:3]=1.Cl.[NH2:11][OH:12].C(=O)([O-])[O-].[Na+].[Na+]>O.C(O)C>[NH2:1][C:2]1[CH:7]=[C:6]([C:8]([NH:11][OH:12])=[NH:9])[CH:5]=[CH:4][N:3]=1参加物
6
実験手順
A stirred mixture of commercially available 2-amino-4-cyano-pyridine [CAS-No. 42182-27-4] (1.0 g, 8.39 mmol), hydroxylamine hydrochloride (1.17 g, 16.8 mmol) and sodium carbonate (0.89 g, 8.39 mol) in water (8 ml) and ethanol (16 ml) was heated under reflux conditions for 3 h. The reaction mixture was evaporated, water (10 ml) was added and the mixture stirred at room temperature for 1 h. The precipitate was collected by filtration to yield the title compound (0.87 g, 68%) as an off-white solid. MS (EI) 152.0 [(M)+]; mp 188° C.
後処理
- temperaturewas heated under reflux conditions for 3 h
- customThe reaction mixture was evaporated
- additionwater (10 ml) was added
- filtrationThe precipitate was collected by filtration
出典と根拠
- ORDレコード
- ord-23fc2512cf304762b3cda44243edf4a0
- 出典データセット
- uspto-grants-2009_03
- 特許番号
- US07504404B2
反応ノート
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