Sodium Hydroxide → 3-(Aminosulfonyl)-4-fluorobenzoic acid

HRID 17848ノート

反応式

HRID 17848 の反応式
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH3:8])=[CH:4][C:3]=1[S:9]([NH2:12])(=[O:11])=[O:10].FC1C=CC(C)=CC=1N.[OH-:22].[Na+].[Mn]([O-])(=O)(=O)=[O:25].[K+]>O>[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([OH:25])=[O:22])=[CH:4][C:3]=1[S:9](=[O:11])(=[O:10])[NH2:12]

参加物

6

反応物 4

HCID 14798Sodium HydroxideHCID 2629702-Fluoro-5-methylanilineHCID 516875Potassium PermanganateHCID 35471672-Fluoro-5-methylbenzenesulfonamide

生成物 1

HCID 6848423-(Aminosulfonyl)-4-fluorobenzoic acid

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
70 °C

実験手順

A suspension of 2-fluoro-5-methylbenzenesulphonamide (5.3 mmol), obtained according to the process described in Step A of Example 1 starting from 2-fluoro-5-methylaniline, in water (50 mL) is heated at 70° C. and then NaOH 10% w/v is added dropwise until the compound has completely dissolved. Potassium permanganate (3 g) is added in small portions. After stirring for 4 hours, the suspension is discharged by filtration in the hot state and the filtrate is brought to pH 1 by adding 12N HCl. The precipitate obtained is collected by filtration, washed with water and dried to yield the title product in the form of a white solid.

後処理

  1. customobtained
  2. dissolutionhas completely dissolved
  3. filtrationthe suspension is discharged by filtration in the hot state
  4. additionby adding 12N HCl
  5. customThe precipitate obtained
  6. filtrationis collected by filtration
  7. washwashed with water
  8. customdried

出典と根拠

ORDレコード
ord-096df4f75def4fc0af51d27068220afa
出典データセット
uspto-grants-2010_06
特許番号
US07741320B2

反応ノート

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