Pyridine → (3-Bromo-5-iodo-phenyl)-carbamic acid methyl ester

HRID 1784885

反応式

HRID 1784885 の反応式
[Br:1][C:2]1[CH:3]=[C:4]([CH:6]=[C:7]([I:9])[CH:8]=1)[NH2:5].N1C=CC=CC=1.Cl[C:17]([O:19][CH3:20])=[O:18]>C(Cl)Cl>[CH3:20][O:19][C:17](=[O:18])[NH:5][C:4]1[CH:6]=[C:7]([I:9])[CH:8]=[C:2]([Br:1])[CH:3]=1

参加物

5

反応物 3

HCID 1049PyridineHCID 6586Methyl chloroformateHCID 454803883-Bromo-5-iodoaniline

生成物 1

HCID 68843615(3-Bromo-5-iodo-phenyl)-carbamic acid methyl ester収率 99.2%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To a stirred solution of 3-bromo-5-iodo-aniline (0.60 g, 2.01 mmol) and pyridine (0.65 mL, 8.06 mmol) in CH2Cl2 (15 mL) at 0° C. was added methyl chloroformate (0.17 mL, 2.22 mmol). The reaction mixture was allowed to warm to room temperature and was stirred for 12 hours. The reaction mixture was washed with twice with 5 mL 1 M HCl and 5 mL brine. The organic layer was dried over Na2SO4 and concentrated to give 0.71 g (99%) of (3-bromo-5-iodo-phenyl)-carbamic acid methyl ester.

後処理

  1. washThe reaction mixture was washed with twice with 5 mL 1 M HCl and 5 mL brine
  2. dry with materialThe organic layer was dried over Na2SO4
  3. concentrationconcentrated

出典と根拠

ORDレコード
ord-5d996fc57382415498ebbc3808665e3b
出典データセット
uspto-grants-2009_03
特許番号
US07504401B2

関連ノート

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