Hydrazine hydrate (1:1) → tert-butyl N-[1-(2-aminoethyl)cyclopropyl]carbamate
反応式
O=C1C2C(=CC=CC=2)C(=O)[N:3]1[CH2:12][CH2:13][C:14]1([NH:17][C:18](=[O:24])[O:19][C:20]([CH3:23])([CH3:22])[CH3:21])[CH2:16][CH2:15]1.O.NN>C(O)C>[NH2:3][CH2:12][CH2:13][C:14]1([NH:17][C:18](=[O:24])[O:19][C:20]([CH3:22])([CH3:21])[CH3:23])[CH2:15][CH2:16]1参加物
4
実験手順
To a solution of 4.57 g (13.83 mmol) of tert-butyl 1-[2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)ethyl]cyclopropylcarbamate in 80 ml of ethanol was added 3.36 ml (69.16 mmol) of hydrazine hydrate and the resulting mixture was heated under reflux for 16 h. The mixture was filtered and washed with diethyl ether. The filtrate was evaporated to dryness to give 2.3 g of pure compound as an orange oil.
後処理
- temperaturethe resulting mixture was heated
- temperatureunder reflux for 16 h
- filtrationThe mixture was filtered
- washwashed with diethyl ether
- customThe filtrate was evaporated to dryness
出典と根拠
- ORDレコード
- ord-176c32185fd343709c7037315fa0835c
- 出典データセット
- uspto-grants-2009_03
- 特許番号
- US07507743B2
反応ノート
読み込み中…