Pyridine → HCID 178433931、化合物

HRID 1786703ノート

反応式

HRID 1786703 の反応式
[O:1]=[C:2]1[C:7]([C:8]([NH:10][NH2:11])=O)=[CH:6][C:5]([C:12]2[CH:17]=[CH:16][N:15]=[CH:14][CH:13]=2)=[N:4][NH:3]1.[C:18]([NH2:21])(=S)[CH3:19].C(N(CC)CC)C.N1C=CC=CC=1>C(O)CCC>[CH3:19][C:18]1[NH:21][C:8]([C:7]2[C:2](=[O:1])[NH:3][N:4]=[C:5]([C:12]3[CH:17]=[CH:16][N:15]=[CH:14][CH:13]=3)[CH:6]=2)=[N:10][N:11]=1

参加物

6

反応物 4

HCID 1049PyridineHCID 8471TriethylamineHCID 2723949ThioacetamideHCID 127902392,3-Dihydro-3-oxo-6-(4-pyridinyl)-4-pyridazinecarboxylic acid hydrazide

生成物 1

HCID 178433931HCID 178433931、化合物

試薬・触媒・溶媒 1

HCID 2631-Butanol溶媒

実験手順

A mixture of 100 mg of 3-oxo-6-pyridin-4-yl-2,3-dihydro-pyridazine-4-carboxylic acid hydrazide, 130 mg thioacetamide, 87 mg triethylamine, 1 ml of pyridine and 5 ml of butanol is refluxed for 15 hours. After cooling and stirring at room temperature, a solid precipitated is collected by filtration, washed with cold isopropanol and dried in vacuo.

後処理

  1. temperatureis refluxed for 15 hours
  2. temperatureAfter cooling
  3. customa solid precipitated
  4. filtrationis collected by filtration
  5. washwashed with cold isopropanol
  6. customdried in vacuo

出典と根拠

ORDレコード
ord-9975cf0fb56142daa5f77fd28abbd97c
出典データセット
uspto-grants-2009_03
特許番号
US07507734B2

反応ノート

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