Acetic Anhydride → Phenol, 2-fluoro-, acetate

HRID 1786822ノート

反応式

HRID 1786822 の反応式
[C:1](OC(=O)C)(=[O:3])[CH3:2].[F:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[OH:15].[OH-].[Na+]>>[C:1]([O:15][C:10]1[CH:11]=[CH:12][CH:13]=[CH:14][C:9]=1[F:8])(=[O:3])[CH3:2]

参加物

4

反応物 3

HCID 7918Acetic AnhydrideHCID 97072-FluorophenolHCID 14798Sodium Hydroxide

生成物 1

HCID 141495Phenol, 2-fluoro-, acetate収率 103%

実験手順

Acetic anhydride (81 cm3, 856 mmol) was added dropwise to a stirred mixture of 2-fluorophenol (60.0 g, 535 mmol) and aqueous sodium hydroxide (4 N, 214 cm3, 856 mmol) at 0° C. After the reaction had been stirred for 30 min the aqueous layer was separated from the organic portion and washed with dichloromethane (150 cm3). The combined organic extracts were washed with aqueous sodium hydroxide solution (4 N, 150 cm3) and then brine (100 cm3). The organic phase was dried (Na2SO4) and the solvent was evaporated in vacuo to afford the title compound (84.9 g, >100%).

後処理

  1. customwas separated from the organic portion
  2. washwashed with dichloromethane (150 cm3)
  3. washThe combined organic extracts were washed with aqueous sodium hydroxide solution (4 N, 150 cm3)
  4. dry with materialThe organic phase was dried (Na2SO4)
  5. customthe solvent was evaporated in vacuo

出典と根拠

ORDレコード
ord-457595687ac04347a558c4b2ae8c9ef7
出典データセット
uspto-grants-2009_03
特許番号
US07507824B2

反応ノート

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