N-bromobutanimide → HCID 86616282、化合物
反応式
[Cl:1][C:2]1[N:3]=[C:4]([CH2:11][CH2:12][CH2:13][NH2:14])[C:5]2[S:10][CH:9]=[CH:8][C:6]=2[N:7]=1.[Br:15]N1C(=O)CCC1=O>C(#N)C>[Br:15][C:8]1[C:6]2[N:7]=[C:2]([Cl:1])[N:3]=[C:4]([CH2:11][CH2:12][CH2:13][NH2:14])[C:5]=2[S:10][CH:9]=1参加物
4
反応条件
- 温度
- 50 °C
実験手順
8.34 g (36.63 mmol) of (2-chlorothieno[3,2-d]pyrimidin-4-yl)propylamine (IV) is dissolved in 60 mL of acetonitrile and 7.89 g (44.32 mmol) of N-bromosuccinimide is added. The reaction mixture is stirred for 16 hours at ambient temperature and for 6 hours at 50° C. Then it is concentrated by evaporation and the residue is combined with water. The precipitate formed is suction filtered, washed, and dried. 7.25 g of product V (61%) is obtained as a powder.
後処理
- concentrationThen it is concentrated by evaporation
- customThe precipitate formed
- filtrationfiltered
- washwashed
- customdried
出典と根拠
- ORDレコード
- ord-1945acaa97ce4d04ac324e577afc72a2
- 出典データセット
- uspto-grants-2009_03
- 特許番号
- US07511045B2
反応ノート
読み込み中…