Thionyl Chloride → HCID 23018027、化合物
反応式
S(Cl)([Cl:3])=O.[F:5][C:6]1[CH:7]=[CH:8][CH:9]=[C:10]2[C:15]=1[N:14]=[C:13]([CH3:16])[CH:12]=[C:11]2[CH2:17]O>C(Cl)(Cl)Cl>[ClH:3].[Cl:3][CH2:17][C:11]1[C:10]2[C:15](=[C:6]([F:5])[CH:7]=[CH:8][CH:9]=2)[N:14]=[C:13]([CH3:16])[CH:12]=1参加物
4
実験手順
At 0° C., 0.75 mL (10.4 mmol) of thionyl chloride was dropped into a solution of 1.00 g (5.23 mmol) of (8-fluoro-2-methylquinolin-4-yl)methanol obtained in the above 1) in chloroform (12 mL) and stirred for 15 hours at room temperature. The reaction mixture was removed under a reduced pressure and then, the residue was washed with ethyl acetate to obtain 1.29 g (yield 100%) of 4-chloromethyl-8-fluoro-2-methylquinoline hydrochloride (XII-124). Its physical property is shown below.
後処理
- customThe reaction mixture was removed under a reduced pressure
- washthe residue was washed with ethyl acetate
出典と根拠
- ORDレコード
- ord-a4a0988fa12e4acb83ea520bc0e7ed4c
- 出典データセット
- uspto-grants-2009_03
- 特許番号
- US07511144B2
反応ノート
読み込み中…