Ammonium formate → 7-Hydroxy-4-(2-methylindol-5-yloxy)quinazoline

HRID 1791620ノート

反応式

HRID 1791620 の反応式
C([O-])=O.[NH4+].C([O:12][C:13]1[CH:22]=[C:21]2[C:16]([C:17]([O:23][C:24]3[CH:25]=[C:26]4[C:30](=[CH:31][CH:32]=3)[NH:29][C:28]([CH3:33])=[CH:27]4)=[N:18][CH:19]=[N:20]2)=[CH:15][CH:14]=1)C1C=CC=CC=1>[Pd].CN(C=O)C>[OH:12][C:13]1[CH:22]=[C:21]2[C:16]([C:17]([O:23][C:24]3[CH:25]=[C:26]4[C:30](=[CH:31][CH:32]=3)[NH:29][C:28]([CH3:33])=[CH:27]4)=[N:18][CH:19]=[N:20]2)=[CH:15][CH:14]=1

参加物

5

反応物 2

HCID 2723923Ammonium formateHCID 220307817-Benzyloxy-4-(2-methylindol-5-yloxy)quinazoline

生成物 1

HCID 1357631147-Hydroxy-4-(2-methylindol-5-yloxy)quinazoline収率 93%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 6228Dimethylformamide溶媒

実験手順

10% Palladium on charcoal (200 mg) followed by ammonium formate (4.34 g, 69 mmol) were added to a solution of 7-benzyloxy-4-(2-methylindol-5-yloxy)quinazoline (1.75 g, 4.58 mmol) in DMF (60 ml). After stirring for 1 hour at ambient temperature, the mixture was filtered. The filtrate was evaporated. The residue was triturated with water, filtered, washed with ethyl acetate, and dried under vacuum to give 7-hydroxy-4-(2-methylindol-5yloxy)quinazoline (1.24 g, 93%).

後処理

  1. filtrationthe mixture was filtered
  2. customThe filtrate was evaporated
  3. customThe residue was triturated with water
  4. filtrationfiltered
  5. washwashed with ethyl acetate
  6. customdried under vacuum

出典と根拠

ORDレコード
ord-66e62c3f593c499ca4a2ecf6732323a2
出典データセット
uspto-grants-2006_07
特許番号
US07074800B1

反応ノート

読み込み中…