Thionyl Chloride → 4-Methyl-1-(quinolin-4-yl)-1H-pyrrole-3-carbonyl chloride

HRID 1792804ノート

反応式

HRID 1792804 の反応式
S(Cl)([Cl:3])=O.[C:5]([C:8]1[C:12]([CH3:13])=[CH:11][N:10]([C:14]2[C:23]3[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=3)[N:17]=[CH:16][CH:15]=2)[CH:9]=1)(O)=[O:6]>C(Cl)(Cl)Cl>[Cl:3][C:5]([C:8]1[C:12]([CH3:13])=[CH:11][N:10]([C:14]2[C:23]3[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=3)[N:17]=[CH:16][CH:15]=2)[CH:9]=1)=[O:6]

参加物

4

反応物 2

HCID 24386Thionyl ChlorideHCID 220249694-Methyl-1-(quinolin-4-yl)-1H-pyrrole-3-carboxylic acid

生成物 1

HCID 220249394-Methyl-1-(quinolin-4-yl)-1H-pyrrole-3-carbonyl chloride収率 100%

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒

実験手順

10 mL (137 mmol) of sulphinyl chloride are added at a temperature in the region of 20° C. under an argon atmosphere to 1 g (3.97 mmol) of 3-carboxy-4-methyl-1-(quinol-4-yl)-1H-pyrrole dissolved in 20 mL of chloroform. After stirring at the reflux point of the solvent for 1 hour, the reaction mixture is concentrated to dryness under reduced pressure (2.7 kPa). The residue is dissolved in 20 mL of chloroform and then brought back to dryness to give 1.07 g (3.97 mmol) of 3-chlorocarbonyl-4-methyl-1-(quinol-4-yl)-1H-pyrrole in the form of a beige-coloured solid which is used directly in the following step.

後処理

  1. concentrationthe reaction mixture is concentrated to dryness under reduced pressure (2.7 kPa)
  2. dissolutionThe residue is dissolved in 20 mL of chloroform

出典と根拠

ORDレコード
ord-e3853d69d4f54b368c8fa00945753e65
出典データセット
uspto-grants-2006_07
特許番号
US07078414B2

反応ノート

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