Thionyl Chloride → HCID 22024978、化合物
反応式
S(Cl)([Cl:3])=O.[C:5]([C:8]1[C:12]([CH3:13])=[CH:11][N:10]([C:14]2[CH:23]=[CH:22][CH:21]=[C:20]3[C:15]=2[CH:16]=[CH:17][CH:18]=[N:19]3)[CH:9]=1)(O)=[O:6]>C(Cl)(Cl)Cl>[ClH:3].[Cl:3][C:5]([C:8]1[C:12]([CH3:13])=[CH:11][N:10]([C:14]2[CH:23]=[CH:22][CH:21]=[C:20]3[C:15]=2[CH:16]=[CH:17][CH:18]=[N:19]3)[CH:9]=1)=[O:6]参加物
4
実験手順
8 mL (110 mmol) of sulphinyl chloride are added to 0.47 g (1.86 mmol) of 3-carboxy-4-methyl-1-(quinolin-5-yl)-1H-pyrrole dissolved in 25 mL of chloroform at a temperature in the region of 20° C. under an argon atmosphere. After stirring for 1.5 hours at the reflux temperature of the solvent, the reaction mixture is concentrated to dryness under reduced pressure (2.7 kPa). The residue is dissolved in 25 mL of chloroform and then concentrated to dryness again, giving 0.58 g (1.86 mmol) of 3-chlorocarbonyl-4-methyl-1-(quinolin-5-yl)-1H-pyrrole hydrochloride in the form of a beige-colored solid, which is used directly in the following step.