Ethyl bromoacetate → HCID 178473177、化合物

HRID 1794042ノート

反応式

HRID 1794042 の反応式
[S:1]1[CH:5]=[CH:4][N:3]=[C:2]1[CH:6]([OH:8])[CH3:7].[Br:9][CH2:10][C:11]([O:13][CH2:14][CH3:15])=[O:12]>C(#N)C>[Br-:9].[CH2:14]([O:13][C:11](=[O:12])[CH2:10][SH:1]1[CH:5]=[CH:4][NH+:3]=[C:2]1[CH:6]([OH:8])[CH3:7])[CH3:15]

参加物

4

反応物 2

HCID 7748Ethyl bromoacetateHCID 99892951-(1,3-Thiazol-2-yl)ethan-1-ol

生成物 1

HCID 178473177HCID 178473177、化合物収率 78.8%

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

A mixture of 1-(2-thiazolyl)ethanol (1.17 g, 8.67 mmole) and ethyl bromoacetate (1.32 g, 8.63 mmole) was heated at 48 C for 18 hr. The reaction mixture was dissolved in acetonitrile (3 mL) and stored at 4 C. After 2 months the crystals which separated were filtered out and washed with 3:7 ether-acetonitrile to yield 2.028 g of the title compound, mp 101–103 C.

後処理

  1. temperaturewas heated at 48 C for 18 hr
  2. customAfter 2 months the crystals which separated
  3. filtrationwere filtered out
  4. washwashed with 3:7 ether-acetonitrile

出典と根拠

ORDレコード
ord-3629852542604e20932501c0660ae383
出典データセット
uspto-grants-2006_04
特許番号
US07022721B1

反応ノート

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