Sodium Iodide → HCID 178497366、化合物

反応式

Cl[CH2:2][C:3]1[NH:7][C:6]2[CH:8]=[CH:9][C:10]([C:12]([O:14][CH3:15])=[O:13])=[CH:11][C:5]=2[N:4]=1.[Na+].[I-].[NH:18]1[CH2:23][CH2:22][O:21][CH2:20][CH2:19]1.C(#[N:26])C>>[O:21]1[CH2:22][CH2:23][N:18]([NH:26][CH2:2][C:3]2[NH:7][C:6]3[CH:8]=[CH:9][C:10]([C:12]([O:14][CH3:15])=[O:13])=[CH:11][C:5]=3[N:4]=2)[CH2:19][CH2:20]1

参加物

反応物 4

HCID 5238Sodium Iodide

HCID 6342Acetonitrile

HCID 8083Morpholine

HCID 178497357HCID 178497357、化合物

生成物 1

HCID 178497366HCID 178497366、化合物収率 81%

実験手順

Methyl 2-(chloromethyl)-1H-benzimidazole-5-carboxylate (5) (0.5 g, 2.2 mmole), NaI (30 mg, 0.2 mmole), in 25 ml of anhydrous acetonitrile, add morpholine (0.48 ml, 5.50 mmole) and stir at ambient temperature for 5 hours. The solution was concentrated under reduced pressure and the resulting yellow solid redissolved in dichloromethane (20 ml) and washed with 10 ml of saturated bicarbonate solution. The organics were dried over anhydrous sodium sulfate and then concentrated to yield a fluffy solid (0.5 g, yield 81%) of 6.