Thionyl Chloride → 2-(4-ethoxyphenyl)acetyl Chloride

HRID 1796452

反応式

HRID 1796452 の反応式
[CH2:1]([O:3][C:4]1[CH:9]=[CH:8][C:7]([CH2:10][C:11]([OH:13])=O)=[CH:6][CH:5]=1)[CH3:2].S(Cl)([Cl:16])=O>C1C=CC=CC=1>[CH2:1]([O:3][C:4]1[CH:9]=[CH:8][C:7]([CH2:10][C:11]([Cl:16])=[O:13])=[CH:6][CH:5]=1)[CH3:2]

参加物

4

反応物 2

HCID 24386Thionyl ChlorideHCID 78631Benzeneacetic acid, 4-ethoxy-

生成物 1

HCID 116297822-(4-ethoxyphenyl)acetyl Chloride収率 94.2%

試薬・触媒・溶媒 1

HCID 241Benzene溶媒

反応条件

温度
80 °C

実験手順

To a stirred solution of (4-ethoxyphenyl)acetic acid (10.0 g, 55.5 mmol) in benzene (100 mL) was added thionyl chloride (50 mL, 68.5 mmol) and the reaction mixture was stirred at 80° C. for 2 hours. The solvent was evaporated in vacuo and the crude product was purified by distillation (bp 86° C., 0.4 Torr) to provide the title compound (10.39 g, 94%) as a yellow oil. MS of methyl ester: MS (ESI) (M+H)+=194.

後処理

  1. customThe solvent was evaporated in vacuo
  2. distillationthe crude product was purified by distillation (bp 86° C., 0.4 Torr)

出典と根拠

ORDレコード
ord-a4973ff8d05341179cbddab8e5d61986
出典データセット
uspto-grants-2006_04
特許番号
US07030139B2

関連ノート

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