反応式
[CH2:1]([O:3][C:4]([C:6]1[NH:7][C:8]([CH:11]=[O:12])=[CH:9][CH:10]=1)=[O:5])[CH3:2].[C-]#N.[K+].[CH3:16][C:17](O)=[O:18]>CCO.O=[Mn]=O>[CH2:1]([O:3][C:4]([C:6]1[NH:7][C:8]([C:11]([O:18][CH2:17][CH3:16])=[O:12])=[CH:9][CH:10]=1)=[O:5])[CH3:2]参加物
6
実験手順
To a mixture of 406A (167 mg, 1.0 mmol), KCN (325.6 mg, 5.0 mmol) in anhydrous EtOH (20 ml) was added AcOH (85.9 μl, 1.5 mmol) followed by activated MnO2 (1.643 g, 20 mmol). The reaction was stirred overnight. After workup, the residue was purified by silica gel flash column chromatography to give 406B (162 mg, 77%) as a pinkish solid (25% EtOAc—hexanes).
後処理
- customAfter workup, the residue was purified by silica gel flash column chromatography
出典と根拠
- ORDレコード
- ord-73c257903a4e4b13ab81a84fd824f0af
- 出典データセット
- uspto-grants-2006_04
- 特許番号
- US07030112B2
関連ノート
読み込み中…