Dimethylformamide → 2-Chloro-3-(1-cyanocyclopropyl)benzoyl chloride
反応式
[Cl:1][C:2]1[C:10]([C:11]2([C:14]#[N:15])[CH2:13][CH2:12]2)=[CH:9][CH:8]=[CH:7][C:3]=1[C:4](O)=[O:5].CN(C)C=O.C(Cl)(=O)C([Cl:24])=O>O1CCCC1>[Cl:1][C:2]1[C:10]([C:11]2([C:14]#[N:15])[CH2:13][CH2:12]2)=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([Cl:24])=[O:5]参加物
5
実験手順
To a solution of 2-chloro-3-(1-cyanocyclopropyl)benzoic acid (16.0 g, 72.2 mmol) in tetrahydrofuran (150 mL) was added N,N-dimethylformamide (0.1 mL), and oxalyl chloride (7.2 mL, 84.0 mmol) was further added dropwise at 0° C., and the mixture was stirred at room temperature for 2.5 hr. The reaction mixture was concentrated under reduced pressure to dryness to give 2-chloro-3-(1-cyanocyclopropyl)benzoyl chloride as a pale-yellow oil.
後処理
- additionwas further added dropwise at 0° C.
- concentrationThe reaction mixture was concentrated under reduced pressure to dryness
出典と根拠
- ORDレコード
- ord-3efb39e4a8124d8a8c324da4e8adb994
- 出典データセット
- uspto-grants-2013_01
- 特許番号
- US08344135B2
反応ノート
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