O-Xylene → Cetirizine

HRID 1803047

反応式

HRID 1803047 の反応式
Cl[CH2:2][CH2:3][O:4][CH2:5][C:6]([OH:8])=[O:7].ClCCO[CH2:13][C:14]([NH2:16])=O.C(OO[CH2:22][CH2:23][Cl:24])(=O)C.ClCCO[CH2:29][C:30]#[N:31].C(=O)([O-])[O-].[Na+].[Na+].C(=O)([O-])[O-].[K+].[K+].[C:44]1([CH3:51])[C:45](C)=[CH:46][CH:47]=[CH:48][CH:49]=1>C1(C)C=CC=CC=1>[Cl:24][C:23]1[CH:22]=[CH:48][C:49]([CH:51]([C:44]2[CH:49]=[CH:48][CH:47]=[CH:46][CH:45]=2)[N:16]2[CH2:14][CH2:13][N:31]([CH2:2][CH2:3][O:4][CH2:5][C:6]([OH:8])=[O:7])[CH2:30][CH2:29]2)=[CH:44][CH:45]=1

参加物

9

反応物 7

HCID 7237O-XyleneHCID 10340Sodium CarbonateHCID 11430Potassium CarbonateHCID 109205842-(2-Chloroethoxy)acetic acidHCID 110189312-(2-chloroethoxy)acetamideHCID 14835913(2-Chloroethoxy)acetonitrileHCID 18435677HCID 18435677、化合物

生成物 1

HCID 2678Cetirizine

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

The compound (I) may be further treated with a 2-chloroethoxy acetic acid derivative such as 2-chloroethoxy acetamide or 2-chloroethoxy acetate or 2-chloroethoxy acetonitrile in the presence of a base such as sodium carbonate or potassium carbonate, and a solvent such as toluene or xylene to obtain the corresponding [2-[4-[(4-chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]acetic acid derivative which on hydrolysis, for example, using sodium hydroxide gives levocetirizine.

出典と根拠

ORDレコード
ord-0709d4e8829142cd93bbdf1360d5fbd2
出典データセット
uspto-grants-2013_01
特許番号
US08350031B2

関連ノート

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