Ammonia → 3-(Propan-2-yl)benzonitrile

HRID 1804541

反応式

HRID 1804541 の反応式
Br[C:2]1[CH:3]=[C:4]([CH:8]([CH3:10])[CH3:9])[CH:5]=[CH:6][CH:7]=1.[Cu](C#N)[C:12]#[N:13].O.N>N1C=CC=CC=1.C1(C)C=CC=CC=1>[CH:8]([C:4]1[CH:3]=[C:2]([CH:7]=[CH:6][CH:5]=1)[C:12]#[N:13])([CH3:10])[CH3:9]

参加物

7

反応物 4

HCID 222AmmoniaHCID 962WaterHCID 1384991-Bromo-3-isopropylbenzeneHCID 178418260HCID 178418260、化合物

生成物 1

HCID 2584403-(Propan-2-yl)benzonitrile

試薬・触媒・溶媒 2

HCID 1049Pyridine溶媒HCID 1140Toluene溶媒

実験手順

5.15 g (25.87 mmol) m-bromo-isopropyl-benzene and 2.69 g (30.04 mmol) copper cyanide are stirred in 2.50 ml of pyridine for 24 hours at 180° C. Then 15 ml of water, 15 ml of toluene and 15 ml conc. ammonia solution are added, then the mixture is extracted. The organic phase is dried and evaporated to dryness.

後処理

  1. extractionthe mixture is extracted
  2. customThe organic phase is dried
  3. customevaporated to dryness

出典と根拠

ORDレコード
ord-656f53ae722d463c8e6a0eff14f36527
出典データセット
uspto-grants-2013_01
特許番号
US08354418B2

関連ノート

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