Dichloromethane → Methyl 5-bromoindoline-7-carboxylate
反応式
[Br:1][C:2]1[CH:3]=[C:4]2[C:8](=[C:9]([C:11]([O:13][CH3:14])=[O:12])[CH:10]=1)[N:7](C(OC(C)(C)C)=O)[CH2:6][CH2:5]2.ClCCl.[OH-].[Na+]>FC(F)(F)C(O)=O>[Br:1][C:2]1[CH:3]=[C:4]2[C:8](=[C:9]([C:11]([O:13][CH3:14])=[O:12])[CH:10]=1)[NH:7][CH2:6][CH2:5]2参加物
5
実験手順
1-(1,1-dimethylethyl) 7-methyl 5-bromo-2,3-dihydro-1H-indole-1,7-dicarboxylate (9 g, 25 mmol) was dissolved in trifluoroacetic acid (6 mL) and stirred at room temperature for 16 hours. Dichloromethane and sodium hydroxide solution (2 M) were added and the organic layer washed twice with sodium hydroxide solution until the aqueous layer pH>7. The organic layer was then concentrated in vacuo to give the title compound as a brown solid (6.5 g).
後処理
- washthe organic layer washed twice with sodium hydroxide solution until the aqueous layer pH>7
- concentrationThe organic layer was then concentrated in vacuo
出典と根拠
- ORDレコード
- ord-681a306a391c47deb1f3587ba27d2205
- 出典データセット
- uspto-grants-2013_01
- 特許番号
- US08354406B2
反応ノート
読み込み中…