Sodium Azide → 1-(azidomethyl)-4-chlorobenzene

HRID 1807481ノート

反応式

HRID 1807481 の反応式
[Cl:1][C:2]1[CH:9]=[CH:8][C:5]([CH2:6]Br)=[CH:4][CH:3]=1.[N-:10]=[N+:11]=[N-:12].[Na+]>CC(C)=O>[N:10]([CH2:6][C:5]1[CH:8]=[CH:9][C:2]([Cl:1])=[CH:3][CH:4]=1)=[N+:11]=[N-:12]

参加物

4

反応物 2

HCID 33557Sodium AzideHCID 693291-(Bromomethyl)-4-chlorobenzene

生成物 1

HCID 111711941-(azidomethyl)-4-chlorobenzene

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

A solution of 4-chlorobenzyl bromide in acetone was treated with NaN3 and refluxed for 3 hours. The reactions was concentrated by 50% and diluted with saturated sodium chloride solution. The reaction was then extracted with Et2O, washed with brine, dried (Na2SO4) and concentrated to give 1-(azidomethyl)-4-chlorobenzene.

後処理

  1. temperaturerefluxed for 3 hours
  2. concentrationThe reactions was concentrated by 50%
  3. additiondiluted with saturated sodium chloride solution
  4. extractionThe reaction was then extracted with Et2O
  5. washwashed with brine
  6. dry with materialdried (Na2SO4)
  7. concentrationconcentrated

出典と根拠

ORDレコード
ord-916cf4eb657048828066668f4c319eef
出典データセット
uspto-grants-2013_01
特許番号
US08357699B2

反応ノート

読み込み中…