2-(2-Nitrophenyl)-3-(trimethylsilyl)-2-propene → 2-(1-Methyl-2-trimethylsilylethyl)phenylamine

HRID 1808295ノート

反応式

HRID 1808295 の反応式
[N+:1]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[C:10](=[CH:12][Si:13]([CH3:16])([CH3:15])[CH3:14])[CH3:11])([O-])=O.[H][H]>O1CCCC1.[Pd]>[NH2:1][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[CH:10]([CH2:12][Si:13]([CH3:15])([CH3:14])[CH3:16])[CH3:11]

参加物

5

反応物 2

HCID 684549542-(2-Nitrophenyl)-3-(trimethylsilyl)-2-propeneHCID 178418361HCID 178418361、化合物

生成物 1

HCID 578833472-(1-Methyl-2-trimethylsilylethyl)phenylamine収率 88%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 8028Tetrahydrofuran溶媒

実験手順

The reaction product of step A [7.2 g] was hydrogenated in tetrahydrofurane over palladium on charcoal at atmospheric pressure and room temperature until the uptake of hydrogen ceased. The catalyst was filtered off and, after evaporation of the solvent, the product was chromatographed on silacagel (eluent: 10% ethylacetate in hexane) to yield 2-(2-aminophenyl)-3-(trimethylsilyl)-propane [4.7 g; 88% purity according to NMR]. This product was used in the next step without further purification.

後処理

  1. filtrationThe catalyst was filtered off
  2. customafter evaporation of the solvent
  3. customthe product was chromatographed on silacagel (eluent: 10% ethylacetate in hexane)

出典と根拠

ORDレコード
ord-d052c0d53109463aa8f7fef434d0f715
出典データセット
uspto-grants-2013_01
特許番号
US08357816B2

反応ノート

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