Hydrochloric Acid → 2-(3-Bromo-5-chlorophenyl)propanoic acid
反応式
C([O:3][C:4](=[O:15])[CH:5]([C:7]1[CH:12]=[C:11]([Cl:13])[CH:10]=[C:9]([Br:14])[CH:8]=1)[CH3:6])C.CO.[Li+].[OH-].Cl>O.C1COCC1>[Br:14][C:9]1[CH:8]=[C:7]([CH:5]([CH3:6])[C:4]([OH:15])=[O:3])[CH:12]=[C:11]([Cl:13])[CH:10]=1参加物
7
実験手順
2-(3-Bromo-5-chloro-phenyl)-propionic acid ethyl ester (2.0 g, 6.9 mmol) in 2:2:1 MeOH:THF:H2O was treated with 1N aqueous LiOH (3 mL) and stirred at room temperature overnight. The mixture was acidified with 10% aqueous HCl (10 mL) and extracted three times with EtOAc. The combined organic layers were concentrated, and the residue was purified by silica gel chromatography to give the title compound.
後処理
- extractionextracted three times with EtOAc
- concentrationThe combined organic layers were concentrated
- customthe residue was purified by silica gel chromatography
出典と根拠
- ORDレコード
- ord-599c298e55234cdda993562fd6b1f280
- 出典データセット
- uspto-grants-2013_01
- 特許番号
- US08362044B2
反応ノート
読み込み中…