Benzaldehyde, 4-(diphenylamino)- → (4-(Diphenylamino)phenyl)methanol

HRID 1814722ノート

反応式

HRID 1814722 の反応式
[C:1]1([N:7]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[C:8]2[CH:15]=[CH:14][C:11]([CH:12]=[O:13])=[CH:10][CH:9]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[BH4-].[Na+]>C(O)C.[OH-].[Na+]>[C:1]1([N:7]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[C:8]2[CH:15]=[CH:14][C:11]([CH2:12][OH:13])=[CH:10][CH:9]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

参加物

5

反応物 2

HCID 77846Benzaldehyde, 4-(diphenylamino)-HCID 4311764Sodium borohydride

生成物 1

HCID 11323339(4-(Diphenylamino)phenyl)methanol収率 92%

試薬・触媒・溶媒 2

HCID 702Ethanol溶媒HCID 14798Sodium Hydroxide溶媒

実験手順

The compound (1) obtained in Example 1-1, that is, 4-(diphenylamino)benzaldehyde, (4.2 g) was dissolved in 50 mL of ethanol and a solution prepared by dissolving 0.29 g of NaBH4 in 0.1 M aqueous solution of NaOH (15 mL) was slowly added thereto. The reactant solution was reacted at room temperature for 4 hours. An organic layer was separated from the reactant solution using methylene chloride and recrystallized in a methylene chloride/hexane solvent, yielding 92% of a white solid. Data of NMR spectra confirmed that the product had the same structure as the compound (2) in the reaction scheme 2.

後処理

  1. customa solution prepared
  2. additionwas slowly added
  3. customThe reactant solution was reacted at room temperature for 4 hours
  4. customAn organic layer was separated from the reactant solution
  5. customrecrystallized in a methylene chloride/hexane solvent

出典と根拠

ORDレコード
ord-0546ba01bb7942039b91eeaf8d2accaa
出典データセット
uspto-grants-2005_04
特許番号
US06878468B2

反応ノート

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