Methylamine → 6H-oxazolo[4,5-e]indole

HRID 18158

反応式

HRID 18158 の反応式
[CH3:1][NH2:2].[OH:3][C:4]1[CH:5]=[C:6]2[C:10](=[CH:11][CH:12]=1)[NH:9][CH:8]=[CH:7]2>CN(C=O)C.O=[Mn]=O>[N:2]1[C:5]2=[C:6]3[C:10](=[CH:11][CH:12]=[C:4]2[O:3][CH:1]=1)[NH:9][CH:8]=[CH:7]3

参加物

5

反応物 2

HCID 6329MethylamineHCID 160545-Hydroxyindole

生成物 1

HCID 113326096H-oxazolo[4,5-e]indole

試薬・触媒・溶媒 2

HCID 14801Manganese dioxide触媒HCID 6228Dimethylformamide溶媒

実験手順

0.5 mmol of methylamine and 4.13 mmol of MnO2 are added to a solution of 0.4 mmol of 5-hydroxy-1H-indole in 3 ml of DMF, and the mixture is stirred at room temperature for 18 hours. The suspension is filtered through Celite and subjected to conventional work-up, giving 6H-oxazolo[4,5-e]indole; ESI 159.

後処理

  1. filtrationThe suspension is filtered through Celite

出典と根拠

ORDレコード
ord-48e2ebd3ce31455ea6dd59c9383f0a06
出典データセット
uspto-grants-2010_06
特許番号
US07741343B2

関連ノート

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