Trifluoroacetic acid → 1-Benzyl-6-fluoro-4-piperidin-4-yl-1H-indole-2-carboxylic acid amide
反応式
FC(F)(F)C([O-])=O.C(OC([N:15]1[CH2:20][CH:19]=[C:18]([C:21]2[CH:29]=[C:28]([F:30])[CH:27]=[C:26]3[C:22]=2[CH:23]=[C:24]([C:38](=[O:40])[NH2:39])[N:25]3[CH2:31][C:32]2[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=2)[CH2:17][CH2:16]1)=O)(C)(C)C.FC(F)(F)C(O)=O>>[CH2:31]([N:25]1[C:26]2[C:22](=[C:21]([CH:18]3[CH2:17][CH2:16][NH:15][CH2:20][CH2:19]3)[CH:29]=[C:28]([F:30])[CH:27]=2)[CH:23]=[C:24]1[C:38]([NH2:39])=[O:40])[C:32]1[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=1参加物
4
実験手順
1-Benzyl-6-fluoro-4-piperidin-4-yl-1H-indole-2-carboxylic acid amide was prepared as trifluoroacetate salt by hydrogenation of 4-(1-Benzyl-2-carbamoyl-6-fluoro-1H-indol-4-yl)-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester, followed by deprotection with trifluoroacetic acid, using the procedure of steps 3 and 4 of Example 2. MS: (M+H)+ 352.