Triethylamine → N-[(1R)-1-(3-Bromophenyl)ethyl]-N'-[4-[(6,7-dimethoxy-4-quinolyl)oxy]-2-(trifluoromethyl)phenyl]urea

HRID 1817440ノート

反応式

HRID 1817440 の反応式
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:12]=1[O:13][CH3:14])[N:9]=[CH:8][CH:7]=[C:6]2[O:15][C:16]1[CH:22]=[CH:21][C:19]([NH2:20])=[C:18]([C:23]([F:26])([F:25])[F:24])[CH:17]=1.C(N(CC)CC)C.ClC(Cl)(O[C:38](=[O:44])OC(Cl)(Cl)Cl)Cl.[Br:46][C:47]1[CH:48]=[C:49]([C@H:53]([NH2:55])[CH3:54])[CH:50]=[CH:51][CH:52]=1>C(Cl)(Cl)Cl>[Br:46][C:47]1[CH:48]=[C:49]([C@H:53]([NH:55][C:38]([NH:20][C:19]2[CH:21]=[CH:22][C:16]([O:15][C:6]3[C:5]4[C:10](=[CH:11][C:12]([O:13][CH3:14])=[C:3]([O:2][CH3:1])[CH:4]=4)[N:9]=[CH:8][CH:7]=3)=[CH:17][C:18]=2[C:23]([F:25])([F:26])[F:24])=[O:44])[CH3:54])[CH:50]=[CH:51][CH:52]=1

参加物

6

反応物 4

HCID 8471TriethylamineHCID 94429TriphosgeneHCID 226371544-[(6,7-Dimethoxy-4-quinolyl)oxy]-2-(trifluoromethyl)anilineHCID 22831503(R)-1-(3-bromophenyl)ethanamine

生成物 1

HCID 57881572N-[(1R)-1-(3-Bromophenyl)ethyl]-N'-[4-[(6,7-dimethoxy-4-quinolyl)oxy]-2-(trifluoromethyl)phenyl]urea収率 29.3%

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒3 回

実験手順

4-[(6,7-Dimethoxy-4-quinolyl)oxy]-2-(trifluoromethyl)aniline (82 mg) was dissolved in chloroform (2 ml) and triethylamine (0.2 ml) to prepare a solution. A solution of triphosgene (70 mg) in chloroform (0.4 ml) was then added to the solution, and the mixture was stirred at room temperature for one hr. Next, a solution of (1R)-1-(3-bromophenyl)ethylamine (70 mg) in chloroform (0.4 ml) was added thereto, and the mixture was stirred at room temperature for 10 hr. The stirred mixture was purified by chromatography on silica gel using chloroform/methanol for development to give the title compound (39 mg, yield 29%).

後処理

  1. stirringthe mixture was stirred at room temperature for 10 hr
  2. customThe stirred mixture was purified by chromatography on silica gel

出典と根拠

ORDレコード
ord-55f7a447af464f2385b01f3981b56d67
出典データセット
uspto-grants-2009_10
特許番号
US07598258B2

反応ノート

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