反応式
[F:1][C:2]1[CH:8]=[C:7]([O:9][C:10]2[C:19]3[C:14](=[CH:15][C:16]([O:22][CH2:23][CH2:24][CH2:25][N:26]4[CH2:31][CH2:30][O:29][CH2:28][CH2:27]4)=[C:17]([O:20][CH3:21])[CH:18]=3)[N:13]=[CH:12][CH:11]=2)[CH:6]=[CH:5][C:3]=1[NH2:4].C(N(CC)CC)C.ClC(Cl)(O[C:43](=[O:49])OC(Cl)(Cl)Cl)Cl.[F:51][C:52]1[CH:53]=[C:54]([CH:59]([NH2:61])[CH3:60])[CH:55]=[CH:56][C:57]=1[F:58]>C(Cl)(Cl)Cl>[F:51][C:52]1[CH:53]=[C:54]([CH:59]([NH:61][C:43]([NH:4][C:3]2[CH:5]=[CH:6][C:7]([O:9][C:10]3[C:19]4[C:14](=[CH:15][C:16]([O:22][CH2:23][CH2:24][CH2:25][N:26]5[CH2:27][CH2:28][O:29][CH2:30][CH2:31]5)=[C:17]([O:20][CH3:21])[CH:18]=4)[N:13]=[CH:12][CH:11]=3)=[CH:8][C:2]=2[F:1])=[O:49])[CH3:60])[CH:55]=[CH:56][C:57]=1[F:58]参加物
6
反応物 4
生成物 1
試薬・触媒・溶媒 1
実験手順
2-Fluoro-4-{[6-methoxy-7-(3-morpholinopropoxy)-4-quinolyl]oxy}-aniline (30 mg) was dissolved in chloroform (3 ml) and triethylamine (0.3 ml) to prepare a solution. A solution of triphosgene (17 mg) in chloroform (0.2 ml) was then added to the solution, and the mixture was stirred at room temperature for 25 min. Next, a solution of 1-(3,4-difluorophenyl)ethylamine (14 mg) in chloroform (0.2 ml) was added thereto, and the mixture was stirred at room temperature for 5 hr. The stirred mixture was purified by chromatography on silica gel using chloroform/methanol for development to give the title compound (27 mg, yield 60%).
後処理
- stirringthe mixture was stirred at room temperature for 5 hr
- customThe stirred mixture was purified by chromatography on silica gel
出典と根拠
- ORDレコード
- ord-ff61ca87a7114d0fa029322f29caa7a0
- 出典データセット
- uspto-grants-2009_10
- 特許番号
- US07598258B2
関連ノート
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