Hydrochloric Acid → HCID 44627932、化合物

HRID 1817989ノート

反応式

HRID 1817989 の反応式
C[O:2][C:3](=[O:16])/[CH:4]=[CH:5]/[C:6]1[CH:7]=[CH:8][CH:9]=[C:10]2[C:14]=1[NH:13][CH:12]=[C:11]2[CH3:15].Cl>C1COCC1.CO.[OH-].[Na+]>[CH3:15][C:11]1[C:10]2[C:14](=[C:6](/[CH:5]=[CH:4]/[C:3]([OH:16])=[O:2])[CH:7]=[CH:8][CH:9]=2)[NH:13][CH:12]=1

参加物

6

反応物 2

HCID 313Hydrochloric AcidHCID 44627931HCID 44627931、化合物

生成物 1

HCID 44627932HCID 44627932、化合物

試薬・触媒・溶媒 3

HCID 887Methanol溶媒HCID 8028Tetrahydrofuran溶媒HCID 14798Sodium Hydroxide溶媒

実験手順

(I-7). To a solution of (E)-3-(3-methyl-1H-indol-7-yl)-acrylic acid methyl ester (2, 180 mg, 0.84 mmol) in THF (5 ml) and methanol (4 ml), NaOH aq. (4 ml) was added at rt. The reaction mixture was stirred at rt over night and then the pH was adjusted to acidic by adding aqueous 2N HCl. The reaction mixture was extracted with EtOAc (2×30 ml). The combined organic phases were washed with water, brine and dried over sodium sulfate. After removal of solvent, 170 mg of I-7 was obtained. 1H-NMR (500 MHz, DMSO-d6).

後処理

  1. extractionThe reaction mixture was extracted with EtOAc (2×30 ml)
  2. washThe combined organic phases were washed with water, brine
  3. dry with materialdried over sodium sulfate
  4. customAfter removal of solvent, 170 mg of
  5. customI-7 was obtained

出典と根拠

ORDレコード
ord-6822edf6532146fca2463bcfe49b7115
出典データセット
uspto-grants-2009_10
特許番号
US07598397B2

反応ノート

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