HCID 4715295、化合物 → 2-ethylbenzenepropanoic acid
反応式
[CH2:1]([C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[CH:9]=[CH:10][C:11]([OH:13])=[O:12])[CH3:2]>C1COCC1.[Pd]>[CH2:1]([C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[CH2:9][CH2:10][C:11]([OH:13])=[O:12])[CH3:2]参加物
4
実験手順
3-(2-Ethyl-phenyl)-acrylic acid (17.00 g, 96.48 mmol) in THF was mixed with Pd/C (1.50 g) and hydrogenated at 50 psi for 6 hours. The resulting mixture was filtered through a pad of celite and the filtrate was concentrated to give 3-(2-ethyl-phenyl)-propionic acid. The acid was reacted with SOCl2 (5.00 mL, 68.55 mmol) and AlCl3 (6.70 g, 50.25 mmol) according to the protocols as outlined in general procedure D to give the title compound.
後処理
- filtrationThe resulting mixture was filtered through a pad of celite
- concentrationthe filtrate was concentrated
出典と根拠
- ORDレコード
- ord-968299d24c5f46e98311c2470e258748
- 出典データセット
- uspto-grants-2009_10
- 特許番号
- US07598417B2
反応ノート
読み込み中…