1-Butanaminium, N,N,N-tributyl-, fluoride, hydrate → 1-[5-fluoro-3-(3-fluoro-benzyl)-7-(1H-pyrrol-3-yl)-benzofuran-2-yl]-ethanone

HRID 18195

反応式

HRID 18195 の反応式
[F:1][C:2]1[CH:3]=[C:4]([C:22]2[CH:26]=[CH:25][N:24]([Si](C(C)C)(C(C)C)C(C)C)[CH:23]=2)[C:5]2[O:9][C:8]([C:10](=[O:12])[CH3:11])=[C:7]([CH2:13][C:14]3[CH:19]=[CH:18][CH:17]=[C:16]([F:20])[CH:15]=3)[C:6]=2[CH:21]=1.O.[F-].C([N+](CCCC)(CCCC)CCCC)CCC>O1CCCC1>[F:1][C:2]1[CH:3]=[C:4]([C:22]2[CH:26]=[CH:25][NH:24][CH:23]=2)[C:5]2[O:9][C:8]([C:10](=[O:12])[CH3:11])=[C:7]([CH2:13][C:14]3[CH:19]=[CH:18][CH:17]=[C:16]([F:20])[CH:15]=3)[C:6]=2[CH:21]=1

参加物

4

反応物 2

HCID 162116731-Butanaminium, N,N,N-tributyl-, fluoride, hydrateHCID 593449101-[5-fluoro-3-(3-fluoro-benzyl)-7-(1-triisopropylsilanyl-1H-pyrrol-3-yl)-benzofuran-2-yl]-ethanone

生成物 1

HCID 593448981-[5-fluoro-3-(3-fluoro-benzyl)-7-(1H-pyrrol-3-yl)-benzofuran-2-yl]-ethanone収率 79%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

1-[5-Fluoro-3-(3-fluoro-benzyl)-7-(1-triisopropylsilanyl-1H-pyrrol-3-yl)-benzofuran-2-yl]-ethanone (0.38 gm, 0.748 mmol) and tetrabutylammonium fluoride hydrate (0.28 gm, 0.89 mmol) were added to tetrahydrofuran (10 ml) and stirred at room temperature for four hours. The solution was concentrated under reduced pressure and purified by column chromatography to give 1-[5-fluoro-3-(3-fluoro-benzyl)-7-(1H-pyrrol-3-yl)-benzofuran-2-yl]-ethanone (0.205 gm, 79% yield).

後処理

  1. concentrationThe solution was concentrated under reduced pressure
  2. custompurified by column chromatography

出典と根拠

ORDレコード
ord-ea46eb9885f64499b73736a5e2e99557
出典データセット
uspto-grants-2010_06
特許番号
US07741326B2

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