Hydrochloric Acid → HCID 23119447、化合物

反応式

C([O:3][C:4](=[O:35])/[C:5](/[CH3:34])=[CH:6]/[C:7]1[C:12]([F:13])=[CH:11][C:10]([C:14](=[O:32])[NH:15][C:16]2[S:17][C:18]3[CH2:28][O:27][C:26]4[C:25]([CH:29]([CH3:31])[CH3:30])=[CH:24][CH:23]=[CH:22][C:21]=4[C:19]=3[N:20]=2)=[CH:9][C:8]=1[F:33])C.CO.[OH-].[Na+].Cl>C1COCC1>[F:33][C:8]1[CH:9]=[C:10]([C:14](=[O:32])[NH:15][C:16]2[S:17][C:18]3[CH2:28][O:27][C:26]4[C:25]([CH:29]([CH3:31])[CH3:30])=[CH:24][CH:23]=[CH:22][C:21]=4[C:19]=3[N:20]=2)[CH:11]=[C:12]([F:13])[C:7]=1/[CH:6]=[C:5](\[CH3:34])/[C:4]([OH:35])=[O:3]

参加物

実験手順

(E)-3-[2,6-difluoro-4-(6-isopropyl-4H-chromeno[4,3-d]thiazol-2-ylcarbamoyl)phenyl]-2-methylacrylic acid ethyl ester (620 mg) was dissolved in THF (2 mL), methanol (2 ml), and 2N sodium hydroxide aqueous solution (2 mL), and the reaction mixture was stirred at room temperature for 3 h. The reaction mixture was acidified with hydrochloric acid and extracted with ethyl acetate. The organic layer was washed with water, and brine, dried over magnesium sulfate, and evaporated. The residue was recrystallized from ethyl acetate to obtain the compound (A1309) 460 mg.