Aminopyrazine → HCID 21034118、化合物
反応式
[F:1][CH:2]([F:13])[O:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[N:10]=[C:11]=[O:12].[NH2:14][C:15]1[CH:20]=[N:19][CH:18]=[CH:17][N:16]=1>C(COC)OC>[F:1][CH:2]([F:13])[O:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[NH:10][C:11]([NH:14][C:15]1[CH:20]=[N:19][CH:18]=[CH:17][N:16]=1)=[O:12]参加物
4
実験手順
2-(Difluoromethoxy)phenylisocyanate (1.0 g, 5.4 mmol) and aminopyrazine (0.51 g, 5.4 mmol) were reacted for 6 hours in refluxing dimethoxyethane (20 mL). The reaction mixture was cooled to room temperature to precipitate the product, which was collected by filtration, washed with ethyl acetate, and dried in vacuo (765 mg, 50%). 1H NMR (300 Mhz, d6-DMSO) δ: 10.49 (br s, 1H), 10.26 (s, 1H), 8.83 (s, 1H), 8.35-8.24 (m, 3H), 7.53-7.00 (m,4H).
後処理
- customto precipitate the product, which
- filtrationwas collected by filtration
- washwashed with ethyl acetate
- customdried in vacuo (765 mg, 50%)
出典と根拠
- ORDレコード
- ord-504ef51e8c3b4503bb4f2f3d68a2d70a
- 出典データセット
- uspto-grants-2009_10
- 特許番号
- US07608618B2
反応ノート
読み込み中…