Sodium Carbonate → HCID 22172587、化合物

HRID 1823689

反応式

HRID 1823689 の反応式
[CH2:1]([NH:8][C:9]([C:11]1[C:16]([NH:17][C:18](=O)[CH2:19][CH:20]([CH3:22])[CH3:21])=[N:15][CH:14]=[CH:13][N:12]=1)=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C(=O)([O-])[O-].[Na+].[Na+]>CN(C=O)C>[CH2:1]([N:8]1[C:9](=[O:10])[C:11]2[C:16](=[N:15][CH:14]=[CH:13][N:12]=2)[N:17]=[C:18]1[CH2:19][CH:20]([CH3:22])[CH3:21])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

参加物

4

反応物 2

HCID 10340Sodium CarbonateHCID 693134583-(3-Methyl-butyrylamino)-pyrazine-2-carboxylic acid benzylamide

生成物 1

HCID 22172587HCID 22172587、化合物収率 33.5%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

Formula 104 where R2 and R3 are H; R5 is Benzyl; R6 is Isopropyl; R6′ is H; X and Y are —C═; and W and Z are —N═: A solution of DMF (100 mL), 3-(3-methyl-butyrylamino)-pyrazine-2-carboxylic acid benzylamide (3.0 g, 9.60 mmol) and sodium carbonate (1.30 g, 12.3 mmol) was stirred at 120° C. overnight. The solvent was removed under reduced pressure and the residue purified by silica gel chromatography using hexane-EtOAc (2:1) as eluent to obtain the desired pyrazopyrimidinone product of Formula 104, 3-benzyl-2-isobutyl-3H-pteridin-4-one (0.948 g, 33.0%). MS (Cl) M/E: 295.1.

後処理

  1. customThe solvent was removed under reduced pressure
  2. customthe residue purified by silica gel chromatography

出典と根拠

ORDレコード
ord-500a31cd79da4534b3755e982aa4d485
出典データセット
uspto-grants-2006_05
特許番号
US07038048B2

関連ノート

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