Chloroform → Hydrochloric Acid
反応式
[C:1]([C:3]1[CH:12]=[CH:11][CH:10]=[CH:9][C:4]=1[C:5]([O:7][CH3:8])=[O:6])#[N:2].[H][H].C(Cl)(Cl)[Cl:16]>CCO.O=[Pt]=O>[NH2:2][CH2:1][C:3]1[CH:12]=[CH:11][CH:10]=[CH:9][C:4]=1[C:5]([O:7][CH3:8])=[O:6].[ClH:16]参加物
7
実験手順
A mixture of methyl 2-cyanobenzoate (1.0 g, 6.2 mmol) and PtO2 (100 mg) in 20 mL EtOH and 1 ml of chloroform was hydrogenated under 50 psi of hydrogen for 2 h. The reaction mixture was filtered through Celite® in a sintered glass funnel and concentrated on a rotary evaporator to give methyl 2-(aminomethyl)benzoate as a HCl salt and this was carried to the next step crude.
後処理
- filtrationThe reaction mixture was filtered through Celite® in a sintered glass funnel
- concentrationconcentrated on a rotary evaporator
出典と根拠
- ORDレコード
- ord-10aab6ff56c340c5a19daf6a4cf52948
- 出典データセット
- uspto-grants-2006_05
- 特許番号
- US07041693B2
反応ノート
読み込み中…