ホームMCPワークベンチSkills
ホームワークベンチ通知マイページ
llms.txt · MCPガイドプライバシーポリシー · 利用規約 · サポートv1.8.0
  1. ホーム
  2. /反応

Ammonium formate → HCID 22144666、化合物

HRID 1824979
ノート
印刷プレビュー

反応式

HRID 1824979 の反応式
[F:1][C:2]1[CH:30]=[C:29]([F:31])[CH:28]=[CH:27][C:3]=1[CH2:4][N:5]1[C:13]2[C:8](=[CH:9][C:10]([N+:14]([O-])=O)=[CH:11][CH:12]=2)[CH:7]=[C:6]1[C:17]([NH:19][C:20]1[CH:25]=[CH:24][C:23]([F:26])=[CH:22][CH:21]=1)=[O:18].C([O-])=O.[NH4+]>C(OCC)(=O)C.C(O)C.[Pd]>[NH2:14][C:10]1[CH:9]=[C:8]2[C:13](=[CH:12][CH:11]=1)[N:5]([CH2:4][C:3]1[CH:27]=[CH:28][C:29]([F:31])=[CH:30][C:2]=1[F:1])[C:6]([C:17]([NH:19][C:20]1[CH:25]=[CH:24][C:23]([F:26])=[CH:22][CH:21]=1)=[O:18])=[CH:7]2
参加物実験手順後処理出典と根拠反応ノート

参加物

6

反応物 2

HCID 2723923Ammonium formate2 回HCID 22144644HCID 22144644、化合物

生成物 1

HCID 22144666HCID 22144666、化合物

試薬・触媒・溶媒 3

HCID 23938Palladium触媒2 回HCID 702Ethanol溶媒HCID 8857Ethyl Acetate溶媒

実験手順

485 mg (1.14 mmol) of 1-(2,4-difluorobenzyl)-N-(4-fluorophenyl)-5-nitro-1H-indole-2-carboxamide from Example XXIV are initially charged in ethyl acetate and ethanol. 287 mg (4.56 mmol) of ammonium formate and 49 mg of palladium on activated carbon (10%) are added. The mixture is heated to reflux, and at 50° C. gas evolves. To bring the reaction to completion, the same amounts of ammonium formate and palladium as above are added. After a further 3 hours at reflux, the mixture is cooled and filtered off through kieselguhr, which is washed with 500 ml of ethanol. The solvent is removed under reduced pressure and the residue is dried.

後処理

  1. temperatureThe mixture is heated
  2. temperatureto reflux
  3. customat 50° C.
  4. customthe reaction to completion
  5. temperatureAfter a further 3 hours at reflux
  6. temperaturethe mixture is cooled
  7. filtrationfiltered off through kieselguhr, which
  8. washis washed with 500 ml of ethanol
  9. customThe solvent is removed under reduced pressure
  10. customthe residue is dried

出典と根拠

ORDレコード
ord-378d339d207348419f28bbc049321e5a
出典データセット
uspto-grants-2006_05
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US07045544B2

反応ノート

読み込み中…

このページの内容参加物実験手順後処理出典と根拠反応ノート