Water → {[4-(5-Chloro-1,3-dioxobenzo [c]azolidin-2-yl)-3-methylphenyl]amino}-n-(phenylsulfonimidoyl)carboxamide

HRID 1828126

反応式

HRID 1828126 の反応式
[Cl:1][C:2]1[CH:41]=[CH:40][C:5]2[C:6](=[O:39])[N:7]([C:10]3[CH:15]=[CH:14][C:13]([NH:16][C:17]([NH:19][S:20]([C:32]4[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=4)(=[N:22]CC4C=CC(OC)=CC=4)=[O:21])=[O:18])=[CH:12][C:11]=3[CH3:38])[C:8](=[O:9])[C:4]=2[CH:3]=1.O.[N+]([O-])([O-])=O.[NH4+]>O=[N+]([O-])[O-].[O-][N+](=O)[O-].[O-][N+](=O)[O-].[O-][N+](=O)[O-].[O-][N+](=O)[O-].[O-][N+](=O)[O-].[Ce+4].[NH4+].[NH4+]>[Cl:1][C:2]1[CH:41]=[CH:40][C:5]2[C:6](=[O:39])[N:7]([C:10]3[CH:15]=[CH:14][C:13]([NH:16][C:17]([NH:19][S:20]([C:32]4[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=4)(=[NH:22])=[O:21])=[O:18])=[CH:12][C:11]=3[CH3:38])[C:8](=[O:9])[C:4]=2[CH:3]=1

参加物

5

反応物 3

HCID 962WaterHCID 22985Ammonium nitrateHCID 20799232{[4-(5-Chloro-1,3-dioxobenzo[c]azolidin-2-yl)-3-methylphenyl]-amino}-n-(n-p-methoxybenzylphenylsulfonimidoyl)carboxamide

生成物 1

HCID 20799234{[4-(5-Chloro-1,3-dioxobenzo [c]azolidin-2-yl)-3-methylphenyl]amino}-n-(phenylsulfonimidoyl)carboxamide

試薬・触媒・溶媒 1

HCID 180504Ceric ammonium nitrate溶媒

実験手順

To 10 mg (0.016 mmol) of {[4-(5-chloro-1,3-dioxobenzo[c]azolidin-2-yl)-3-methylphenyl]-amino}-N-(N-p-methoxybenzylphenylsulfonimidoyl)carboxamide dissolved in 380 μL of CAN followed by 96 uL of water was added 70 mg (0.13 mmol) of cerric ammonium nitrate. After 20 m, the reaction was complete and purified by RP-HPLC to give 1.8 mg (23%) after lyophilization. ES-MS (M+H)+=469 (Cl).

後処理

  1. custompurified by RP-HPLC
  2. customto give 1.8 mg (23%) after lyophilization

出典と根拠

ORDレコード
ord-08f61b8fb85b486e8a691999916966da
出典データセット
uspto-grants-2006_06
特許番号
US07056926B2

関連ノート

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