Formamide → N-(1-pyridin-4-ylethyl)formamide

HRID 1831806ノート

反応式

HRID 1831806 の反応式
[N:1]1[CH:6]=[CH:5][C:4]([C:7](=O)[CH3:8])=[CH:3][CH:2]=1.[CH:10]([NH2:12])=[O:11].[OH-].[Na+]>C(O)=O.O>[N:1]1[CH:6]=[CH:5][C:4]([CH:7]([NH:12][CH:10]=[O:11])[CH3:8])=[CH:3][CH:2]=1

参加物

6

反応物 3

HCID 713FormamideHCID 142824-AcetylpyridineHCID 14798Sodium Hydroxide

生成物 1

HCID 2771720N-(1-pyridin-4-ylethyl)formamide

試薬・触媒・溶媒 2

HCID 284Formic Acid溶媒2 回HCID 962Water溶媒

実験手順

1-Pyridin-4-yl-ethanone (24.2 g, 199.77 mmol) and 10 ml of formic acid were heated to 180° C. and formamide (126 g, 2.797 mol) in 10 ml of formic acid was added within 30 min. The mixture was stirred for 90 min., cooled and poured in 100 ml of water. After addition of conc. sodium hydroxide solution until pH13 the product was extracted with diethyl-ether. The organic layer was dried with MgSO4 and evaporated. Purification by distillation (165° C./4 mbar) yields pure product.

後処理

  1. temperaturecooled
  2. extractionwas extracted with diethyl-ether
  3. dry with materialThe organic layer was dried with MgSO4
  4. customevaporated
  5. customPurification
  6. distillationby distillation (165° C./4 mbar)
  7. customyields pure product

出典と根拠

ORDレコード
ord-51a7bbae96154048b61fe7ecbbdc2a52
出典データセット
uspto-grants-2006_06
特許番号
US07067665B2

反応ノート

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