Dimethylformamide → 2-[(2,6-Dichloropyridin-3-yl)oxy]propanoyl chloride

HRID 1833830ノート

反応式

HRID 1833830 の反応式
[Cl:1][C:2]1[C:7]([O:8][CH:9]([CH3:13])[C:10](O)=[O:11])=[CH:6][CH:5]=[C:4]([Cl:14])[N:3]=1.CN(C)C=O.S(Cl)([Cl:22])=O>C(Cl)(Cl)Cl>[Cl:1][C:2]1[C:7]([O:8][CH:9]([CH3:13])[C:10]([Cl:22])=[O:11])=[CH:6][CH:5]=[C:4]([Cl:14])[N:3]=1

参加物

5

反応物 3

HCID 6228DimethylformamideHCID 24386Thionyl ChlorideHCID 129061732-[(2,6-Dichloropyridin-3-yl)oxy]propanoic acid

生成物 1

HCID 129061742-[(2,6-Dichloropyridin-3-yl)oxy]propanoyl chloride

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒2 回

実験手順

23.6 g (0.1 mole) of 2-[(2,6-dichloro-3-pyridyl)oxy]-propionic acid, 150 ml of chloroform and 1.5 ml of dimethylformamide are heated with stirring to 55°, and in the course of 1 hour a solution of 18 g (0.15 mole) of thionyl chloride in 40 ml of chloroform is added dropwise. The reaction mixture is subsequently refluxed for 16 hours and is afterwards concentrated in vacuo. The product obtained is used directly for further reactions.

後処理

  1. temperatureThe reaction mixture is subsequently refluxed for 16 hours
  2. concentrationis afterwards concentrated in vacuo
  3. customThe product obtained

出典と根拠

ORDレコード
ord-44bb6621ad28421f8c8cf23cd617d584
出典データセット
uspto-grants-1978_01
特許番号
US04067725

反応ノート

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