Ethanolamine → N-(2-hydroxyethyl)-2,4-dimethylbenzenesulfonamide

HRID 1834345ノート

反応式

HRID 1834345 の反応式
[CH2:1]([CH2:3][NH2:4])[OH:2].C(N(CC)CC)C.[CH3:12][C:13]1[CH:18]=[C:17]([CH3:19])[CH:16]=[CH:15][C:14]=1[S:20](Cl)(=[O:22])=[O:21]>O1CCCC1>[OH:2][CH2:1][CH2:3][NH:4][S:20]([C:14]1[CH:15]=[CH:16][C:17]([CH3:19])=[CH:18][C:13]=1[CH3:12])(=[O:22])=[O:21]

参加物

5

反応物 3

HCID 700EthanolamineHCID 8471TriethylamineHCID 69109Benzenesulfonyl chloride, 2,4-dimethyl-

生成物 1

HCID 15942937N-(2-hydroxyethyl)-2,4-dimethylbenzenesulfonamide

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒2 回

実験手順

To 40 parts of tetrahydrofuran are added 1.5 parts of ethanolamine and 2.5 parts of triethylamine. Into this solution, 10 parts of tetrahydrofuran containing 5 parts of 2,4-dimethylbenzenesulfonyl chloride is dropped with stirring. After the dropping, the resultant mixture is stirred as it is for 30 minutes. Subsequently, the salt is removed by filtration, and the filtrate is freed from the solvent to form a solid. This solid is recrystallized from isopropyl ether to obtain 3.6 parts of N-2-hydroxyethyl-2,4-dimethylbenzenesulfonamide, m.p. 70°-72° C.

後処理

  1. customSubsequently, the salt is removed by filtration
  2. customto form a solid
  3. customThis solid is recrystallized from isopropyl ether

出典と根拠

ORDレコード
ord-20408ad42c75413db49e303829290e68
出典データセット
uspto-grants-1978_01
特許番号
US04070176

反応ノート

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