Hydrochloric Acid → 3-(Thien-2-yl)benzoic acid

HRID 1835448ノート

反応式

HRID 1835448 の反応式
C[O:2][C:3]([C:5]1[CH:6]=[C:7]([C:11]2[S:12][CH:13]=[CH:14][CH:15]=2)[CH:8]=[CH:9][CH:10]=1)=[O:4].[OH-].[Na+].Cl>CO.O1CCCC1>[C:3]([C:5]1[CH:6]=[C:7]([C:11]2[S:12][CH:13]=[CH:14][CH:15]=2)[CH:8]=[CH:9][CH:10]=1)([OH:4])=[O:2]

参加物

6

反応物 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 4128465Methyl 3-(2-thienyl)benzoate

生成物 1

HCID 7368613-(Thien-2-yl)benzoic acid収率 93.6%

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 8028Tetrahydrofuran溶媒

反応条件

温度
60 °C

実験手順

To a solution of 2-(3-methoxycarbonylphenyl)thiophene (1.29 g) in methanol (15 ml) and tetrahydrofuran (5 ml) was added an aqueous solution of sodium hydroxide (1N, 8.87 ml) followed by stirring for 2 hours at 60° C. To the mixture was added hydrochloric acid (1N, 10 ml). The resulting precipitate was collected by filtration and dried to give 2-(3-carboxyphenyl)thiophene (1.13 g, 93.4%).

後処理

  1. filtrationThe resulting precipitate was collected by filtration
  2. customdried

出典と根拠

ORDレコード
ord-2ae6f0e1d28e47dd86c0fe3a409b7781
出典データセット
uspto-grants-2004_08
特許番号
US06770667B1

反応ノート

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