Formaldehyde → Hydroxyethyl methyltolylamine

HRID 1835901ノート

反応式

HRID 1835901 の反応式
[OH:1][CH2:2][CH2:3][NH:4][C:5]1[CH:10]=[CH:9][C:8]([CH3:11])=[CH:7][CH:6]=1.[H][H].[CH2:14]=O>[Pd].O>[CH3:14][N:4]([CH2:3][CH2:2][OH:1])[C:5]1[CH:10]=[CH:9][C:8]([CH3:11])=[CH:7][CH:6]=1

参加物

6

反応物 3

HCID 712FormaldehydeHCID 2200082-p-Tolylamino-ethanolHCID 178418361HCID 178418361、化合物2 回

生成物 1

HCID 76094Hydroxyethyl methyltolylamine

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 962Water溶媒

反応条件

温度
120 °C

実験手順

N-(2-hydroxyethyl)-p-toluidine, 50 g, was combined with 1 g 5% palladium on carbon catalyst and charged to a pressure reactor. The pressure reactor was heated to 120° C. and fed hydrogen gas to maintain 120 psig pressure. Formaldehyde, 178 g 37% solution in water, was fed to the pressure reactor over 10 hours. After hydrogen uptake ceased, the reaction mass was filtered to remove catalyst and decanted to separate the aqueous phase.

後処理

  1. additioncharged to a pressure reactor
  2. temperatureto maintain 120 psig pressure
  3. filtrationthe reaction mass was filtered
  4. customto remove catalyst
  5. customdecanted
  6. customto separate the aqueous phase

出典と根拠

ORDレコード
ord-63cdedb8f8264a4daffc54fbe30d9c76
出典データセット
uspto-grants-2004_08
特許番号
US06774193B2

反応ノート

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