Hydrochloric Acid → HCID 15922632、化合物
反応式
[F:1][C:2]1[CH:3]=[CH:4][C:5]([CH3:11])=[C:6]([CH2:8][C:9]#N)[CH:7]=1.[CH3:12]I.[H-].[Na+].Cl.C[N:18]([CH3:21])C=O>C(OCC)(=O)C>[F:1][C:2]1[CH:3]=[CH:4][C:5]([CH3:11])=[C:6]([C:8]([CH3:12])([CH3:9])[C:21]#[N:18])[CH:7]=1参加物
7
実験手順
5.25 g of (5-fluoro-2-methylphenyl)acetonitrile and 5.25 ml of methyl iodide are dissolved in 70 ml of dimethylformamide and mixed with 2.7 g of sodium hydride (80%) for 2.5 hours while being cooled with ice. After 3 hours at 0° C. and 16 hours at room temperature, it is mixed with ice water and ethyl acetate, acidified with 1 M hydrochloric acid, and the ethyl acetate phase is washed with water, dried (Na2SO4) and concentrated by evaporation. 6.1 g of 2-(5-fluoro-2-methylphenyl)-2-methylpropionitrile is obtained as an oil.
後処理
- temperaturewhile being cooled with ice
- washthe ethyl acetate phase is washed with water
- dry with materialdried (Na2SO4)
- concentrationconcentrated by evaporation
出典と根拠
- ORDレコード
- ord-019f70eed729493ebe983652052bb189
- 出典データセット
- uspto-grants-2004_08
- 特許番号
- US06777409B2
反応ノート
読み込み中…