Ethyl bromoacetate → HCID 178473177、化合物

HRID 1836732ノート

反応式

HRID 1836732 の反応式
[S:1]1[CH:5]=[CH:4][N:3]=[C:2]1[CH:6]([OH:8])[CH3:7].[Br:9][CH2:10][C:11]([O:13][CH2:14][CH3:15])=[O:12]>C(#N)C>[Br-:9].[CH2:14]([O:13][C:11](=[O:12])[CH2:10][SH:1]1[CH:5]=[CH:4][NH+:3]=[C:2]1[CH:6]([OH:8])[CH3:7])[CH3:15]

参加物

4

反応物 2

HCID 7748Ethyl bromoacetateHCID 99892951-(1,3-Thiazol-2-yl)ethan-1-ol

生成物 1

HCID 178473177HCID 178473177、化合物収率 78.8%

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

A mixture of 1-(2-thiazolyl)ethanol (1.17 g, 8.67 mmole) and ethyl bromoacetate (1.32 g, 8.63 mmole) was heated at 48 C. for 18 hr. The reaction mixture was dissolved in acetonitrile (3 mL) and stored at 4 C. After 2 months the crystals which separated were filtered out and washed with 3:7 ether-acetonitrile to yield 2.028 g of the title compound, mp 101-103 C.

後処理

  1. temperaturewas heated at 48 C
  2. customAfter 2 months the crystals which separated
  3. filtrationwere filtered out
  4. washwashed with 3:7 ether-acetonitrile

出典と根拠

ORDレコード
ord-18318557348147dfa7f92c4c749e9a23
出典データセット
uspto-grants-2004_08
特許番号
US06777557B2

反応ノート

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