Tetrahydrofuran → 2-(2-Methoxy-3-pyridinyl)ethanol

HRID 1837704ノート

反応式

HRID 1837704 の反応式
[CH3:1][O:2][C:3]1[C:8]([CH2:9][C:10](O)=[O:11])=[CH:7][CH:6]=[CH:5][N:4]=1.[H-].[Al+3].[Li+].[H-].[H-].[H-].C1COCC1.[OH-].[Na+]>O>[CH3:1][O:2][C:3]1[C:8]([CH2:9][CH2:10][OH:11])=[CH:7][CH:6]=[CH:5][N:4]=1

参加物

6

反応物 4

HCID 8028TetrahydrofuranHCID 14798Sodium HydroxideHCID 21226445Aluminium lithium hydrideHCID 226783192-Methoxy-3-pyridineacetic acid

生成物 1

HCID 140623082-(2-Methoxy-3-pyridinyl)ethanol収率 54.6%

試薬・触媒・溶媒 1

HCID 962Water溶媒2 回

実験手順

2.4 g of (2-methoxy-3-pyridyl)acetic acid, 550 mg of lithium aluminum hydride and 20 ml of THF were stirred at room temperature for 0.5 hour. 0.27 ml of water, 3.9 ml of a 3.8N aqueous sodium hydroxide and 0.78 ml of water were successively added thereto, and the resulting solid was filtered off. The filtrate was evaporated, and the residue was purified by silica gel chromatography (hexane:ethyl acetate=2:1, subsequently 1:1), to give 1.2 g of a yellow oil.

後処理

  1. filtrationthe resulting solid was filtered off
  2. customThe filtrate was evaporated
  3. customthe residue was purified by silica gel chromatography (hexane

出典と根拠

ORDレコード
ord-1f5f935e8a8a4cf991801daa2511d6f5
出典データセット
uspto-grants-2004_08
特許番号
US06784192B2

反応ノート

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