Chlorotrimethylsilane → HCID 22677668、化合物

HRID 1837962ノート

反応式

HRID 1837962 の反応式
[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]1[CH:11]=[CH:10][C:9]([OH:12])=[CH:8][CH:7]=1.CCN(CC)CC.[CH3:20][Si:21](Cl)([CH3:23])[CH3:22]>C1COCC1>[CH3:20][Si:21]([CH3:23])([CH3:22])[O:12][C:9]1[CH:10]=[CH:11][C:6]([C:2]2[S:1][CH:5]=[CH:4][CH:3]=2)=[CH:7][CH:8]=1

参加物

5

反応物 3

HCID 6397ChlorotrimethylsilaneHCID 8471TriethylamineHCID 35641974-Thiophen-2-ylphenol

生成物 1

HCID 22677668HCID 22677668、化合物

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

To a solution of 4-(2-thienyl)phenol in anhyd. THF (10 mL) was added Et3N (0.9 mL, 6.5 mmol), followed by TMSCl (0.4 mL, 3.2 mmol). The reaction mixture was stirred at room temperature overnight, then filtered and concentrated under reduced pressure to give 2-(4-trimethylsilyloxyphenyl)thiophene: TLC (20% EtOAc/hex) Rf 0.69. This material was used without further purification.

後処理

  1. filtrationfiltered
  2. concentrationconcentrated under reduced pressure

出典と根拠

ORDレコード
ord-798e47486a944d268588d2a9290458af
出典データセット
uspto-grants-2004_08
特許番号
US06784167B2

反応ノート

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